Industrialization of high-precision Astragalus extract
Huajiao Group and all its employees firmly believe that quality is the life of an enterprise and the criterion for all actions. Therefore, we strictly follow the requirements of GMP and the effective quality management system operation procedures in all links such as raw material procurement, workshop production, product inspection, product warehousing, packaging and transportation. In order to ensure the quality of finished products, we strictly implement documented procedures from market research, product development, supplier management, warehouse management, resource management, product production, product inspection, sales management, sales service and other process management, so as to achieve preventive management and ensure product quality. In addition, our quality control department is equipped with advanced precision testing instruments, such as high-performance liquid chromatography, gas chromatograph, infrared, ultraviolet, etc., and full-time quality control personnel strictly control every link of production. Inspection data such as active ingredients, drying loss, ash content, heavy metals, residual solvents, and microbial indicators are fully and detailedly recorded. Items that the company cannot self-check, such as ETO, pesticide residues, PAHs, mycotoxins, alkaloids, etc., will be regularly sent to internationally recognized third-party laboratories for testing. Thereby ensuring that product quality is foolproof. In addition to self-testing according to the 2020 edition of the Chinese Pharmacopoeia, the content of each batch of our company's Astragalus extracts (astragaloside IV and cycloastragenol) is also sent to the Analysis and Testing Center of the Chengdu Branch of the Chinese Academy of Sciences for testing. The test results should be within the range of ±2%, and the lower value is taken as the report result. The test report and product quality inspection form are provided with the goods. We also send our products to FDA, SGS, Eurofins, Intertek, TUV and other internationally recognized third-party organizations for testing from time to time.
Astragalus Extract and Astragalus Polysaccharide Industry Chain Project
The unique enzyme treatment cell wall breaking technology of the core technical team of Huajiao Group ensures that the natural active ingredients are extracted to the greatest extent. The company's main business is to research and develop, separate and purify monomers with significant biological activity from traditional Chinese medicine and natural botanicals. The main products are astragalus extracts (astragaloside IV, cycloastragenol, astragalus polysaccharides, astragalus ratio extracts, calycosin glucoside, etc.). The company's main business is to research and develop, separate and purify monomers with significant biological activity from traditional Chinese medicine and natural botanicals. Representative products include astragaloside IV, cycloastragenol, calycosin glucoside, astragalus polysaccharides, etc.
The company has recently established a scientific research and operation center in Datong, and has designed and built an extraction and refining production workshop in accordance with GMP requirements; the R&D center has a high-quality technical R&D team, equipped with advanced instruments and equipment such as HPLC, UV and detection methods, focusing on technical research of new products and new processes. The extraction and refining production workshop is mainly used to produce monomers with significant biological activity developed by our company for domestic and foreign markets. The company's newly built extraction and refining production workshop has an annual processing capacity of 40,000 tons of medicinal materials. The workshop has a complete set of equipment for medicinal material pretreatment, extraction, concentration, extraction, column chromatography separation, membrane separation, refrigeration, spray drying and vacuum drying. All products of the company are produced under GMP conditions and are strictly tested by modern detection methods such as MS, NMR, HPLC, etc.
At present, the conventional mass production includes 0.3% to 98% astragaloside Ⅳ, 5% to 98% cycloastragenol, 20% to 80% astragalus polysaccharide, astragalus extract, 0.5% to 5% calycosin glucoside, etc.
The Ministry of Agriculture and Rural Affairs has issued Announcement No. 194, stating that from New Year's Day 2020, my country will completely ban the addition of antibiotics to feed to reduce the harm caused by the abuse of antibiotics and maintain the safety of animal-based food and public health.
Astragalus polysaccharide has the effects of improving immunity and resisting viruses, making it widely used in animal breeding as a new type of immune enhancer. Replacing chemical antibiotics is a rigid demand for domestic food safety.
The market demand gap for a single product, feed additive Astragalus polysaccharide, will be RMB 14 billion in 2022.
1) Astragalus can promote animal growth
Astragalus polysaccharide has the function of improving the utilization of nutrients and promoting animal growth. Astragalus polysaccharide contains amino acids, vitamins, trace elements and other nutrients. As a feed additive, it can significantly increase the growth rate of livestock and poultry, enhance the body's resistance, and improve the quality and output of meat, eggs and milk.
2) The effect of Astragalus polysaccharide on the liver: It can promote the synthesis of liver cells and DNA RNA, reduce the lesions caused by hepatotoxic substances, enhance the liver's detoxification function, and protect liver cells. At the same time, it increases the feed intake of livestock and poultry, thereby promoting the growth and development of livestock and poultry.
3) Application of Astragalus Polysaccharide in the Reproduction of Breeding Livestock and Poultry
Astragaloside has the functions of stabilizing cells, anti-aging, anti-free radicals and peroxidation. Long-term and regular use can significantly improve the service life and efficiency of breeding livestock and poultry. The application fields of astragaloside IV are Chinese medicine intermediates, Chinese veterinary medicine intermediates, and biological feed additives.
Since Chinese veterinary medicines do not pose a threat to food safety, they will gradually replace chemical medicines to a large extent. In 2022, the scale of the veterinary medicine industry is expected to exceed 80 billion yuan, and by 2027, the national market scale of the veterinary medicine industry is expected to reach 139.572 billion yuan. Market scale: The Chinese veterinary medicine market is showing a clear upward trend. Provide various types of Chinese veterinary medicine intermediates that meet the standards for member units of the China Association of Traditional Chinese Veterinary Medicine.
Astragalus Extract Cycloastragenol Industrial Chain Project
Cycloastragenol (Chromosome Telomere Theory) - the only substance that stimulates telomerase to reverse growth. The only substance that resists aging and prolongs life. The 2009 Nobel Prize in Physiology or Medicine was awarded to Elizabeth Blackburn, Carol Greider and Jack Szostak for discovering chromosome telomeres. Proof: Telomeres are related to aging and cancer. By studying telomeres, we can find ways to resist aging and prevent cancer. We can delay aging by protecting telomeres, or by controlling telomeres, such as by inhibiting telomerase to specifically control the division of cancer cells.
Cycloastragenol is the aglycone of astragaloside IV, which is mainly found in the traditional Chinese medicine Astragalus and can be prepared from astragaloside IV. Studies have found that this compound can increase the activity of telomerase, thereby delaying cell aging. At the same time, cycloastragenol also has good pharmacological activities such as anti-HIV, prevention and treatment of abdominal aortic aneurysm, anti-inflammatory and anti-oxidative stress.
Cycloastragenol, the only substance discovered in the world, is the only substance that can stimulate the reverse growth of telomeres.
Hundreds of billions of health care market. 98% high purity, international 480,000/kg (RMB) (German price in May 2022) The biological high-value design of Astragalus extract makes full use of the existing Astragalus plant resources in Datong, Shanxi Province, and is market-oriented. It purifies intermediates through a deep processing holographic biological production line, and separates and purifies all the effective ingredients contained in the roots, stems, leaves, flowers and fruits at one time to meet the needs of Chinese veterinary intermediates, biological feed intermediates, biological pesticide additive intermediates, and Chinese medicine intermediates.
Constructing high-value utilization of regional biological resources - helping rural revitalization
The company is an expert in plant structure analysis, multi-target plant extraction and natural product application in my country, and is one of the few large-scale phytoene (plant graphene) production companies in the world. The company has more than 400 technical patents, original ISM artificial induction coupled microbial fermentation technology, E-SM coupled bioreactor, and phytoene carbon nanomaterial production technology, which can achieve the analysis, extraction and phytoene quantum carbonization of more than 2,000 kinds of plant/fungus active ingredients. It has a wide range of application scenarios, high extraction efficiency and low extraction cost. It can be widely used in life sciences, new energy, new materials, soil improvement, agricultural planting, environmental protection and other industries. The advantages of the industrialization of biological high-value design of astragalus extracts are as follows:
1. Multi-plant purification: A deep processing holographic biological production line can meet the purification needs of all plants.
2. One-time multi-target purification: one-time addition, multiple active ingredients are separated at one time.
3. High-purity standardized intermediates: high purity, removal of pesticide residues and heavy metals, meeting the market demand for high-quality products.
4. Low cost: Microbial coupling biotechnology improves target content, one-time multi-target purification technology reduces raw material costs.
Industrial research and development direction: holographic biochemical and physical coupling system (whole plant and full component extraction) phytoene preparation (below 3 nanometers). It is an expert in plant structure analysis and natural product application, and one of the outstanding companies in China's medicinal plant chemistry industry. One of the few large-scale bio-based graphene production companies in the world (leading in China). With independent core technology, we have created a natural product full industry chain cluster. At present, ten major industrial clusters have been formed: agriculture, breeding, printing and dyeing and plant inks, health products, fine chemicals, new materials, new energy, environmental protection, big data and intelligent equipment. The company's natural medicines, health foods, cosmetics and other raw materials and intermediates. It is a pharmaceutical, health food, cosmetics and tobacco additive, and has a certain influence and good reputation in the international market.
Astragalus manufacturing base promotes the development of Astragalus industry in Shanxi Province
Astragalus: Astragalus is a Chinese medicine. It is the root of Astragalus mongolica or Astragalus membranaceus, a plant of the genus Astragalus in the Leguminosae family. It has the effects of strengthening the spleen and replenishing the middle, raising yang and lifting the sunken, strengthening the body's defense and strengthening the exterior, promoting diuresis, and removing toxins and promoting muscle regeneration. It is mainly used to treat spleen qi deficiency syndrome, lung qi deficiency syndrome, qi deficiency and spontaneous sweating syndrome, qi and blood deficiency, sores that are difficult to ulcerate and decay, or sores that are difficult to heal for a long time. Astragalus is a perennial herb with a deep taproot. Its roots are used for medicinal purposes and are mostly dug in spring and autumn. It is a nourishing health food. Due to its excellent quality, wide range of uses and low production, it is always in short supply in the market.
It mainly produces astragalus polysaccharides, astragaloside IV, flavonoids, cycloastragenol and other intermediates and products with huge international and domestic demand. It mainly meets the international and domestic rigid demand markets such as pharmaceutical intermediates, biological feed, Chinese veterinary medicine, and alternative antibiotics for biological pesticides. The effective ingredients and functions of astragalus are as follows:
Astragalus polysaccharide: Astragalus polysaccharide function: enhance the body's immune function.
Cycloastragenol: Cycloastragenol is an effective telomerase activator that can extend telomeres and prolong life. 2. It has antioxidant, anti-inflammatory, anti-aging, anti-apoptosis and cardiovascular protection effects.
Astragaloside IV: enhances the body's immunity and improves the body's disease resistance; antiviral effect.
Anti-stress effect: It can prevent adrenal hyperplasia and thymus atrophy during the stress response alert period.
As a growth promoter; astragaloside IV can improve cardiopulmonary function.
Flavonoids: prevent cardiovascular and cerebrovascular diseases, anti-aging and inhibit the occurrence of cancer; can better meet people's medical and health needs to resist diseases and enhance physical fitness.
Domestic Chinese medicine market situation: In 2022, the global Chinese herbal medicine sales market is about 110 billion US dollars. Chinese herbal medicine accounts for only about 10% of the international Chinese herbal medicine market, far lower than Europe, the United States, and Japan. From January to June 2023, China's exports of traditional Chinese medicines were only 170 million US dollars, a year-on-year decrease of 17.95%. There are many reasons for the backwardness of my country's Chinese herbal medicine market, which we believe include the following points:
Lack of theoretical guidance from experimental science: Traditional Chinese medicine is a typical empirical science. It is a set of theoretical systems and production and treatment methods summarized from a large number of practical activities. It lacks theoretical guidance from experimental science and its methods are not rigorous.
Backward preparation methods: my country basically uses boiling, fumigation and other methods to prepare Chinese medicine. Chinese medicine prepared by this method has low purity, many impurities, high toxicity (all medicines are toxic), and slow efficacy. This has seriously affected the popularization and promotion of Chinese medicine, and even affected the export of Chinese medicine.
In recent years, some companies have tried to extract active ingredients from Chinese medicinal materials for use as medicine, but most of them have failed due to backward technology, low purity and unclear efficacy.
Lack of logical data support for medicinal properties and pharmacology: Traditional Chinese medicine uses the qualitative logical expression of Yin-Yang and the Five Elements, and rarely studies the pharmacology and medicinal properties of Chinese medicine from a molecular level and quantitative perspective. As a result, the medicinal properties of Chinese medicine cannot be expressed quantitatively, the efficacy is difficult to scientifically verify, and the persuasiveness is not strong.
The way out for the modernization of Chinese medicine in my country: To realize the modernization of Chinese medicine, the following points must be met at the same time:
1. National policy support.
2. Quantitative pharmacological and efficacy research based on experimental foundations and scientific testing methods.
3. High-efficiency, high-purity and low-cost purification technology and process.
4. Powerful promotion.
The current status of the development of Chinese medicine in the world: Europe, the United States, Japan and South Korea attach great importance to the research and development of natural extracts - Chinese herbal medicine is becoming more and more popular around the world. In recent years, Europe, the United States, Japan and South Korea have attached great importance to extracting natural ingredients from animals and plants and making them into health products or medicines, and the market has developed rapidly. Japan has vigorously developed Kampo medicine, and its Kampo medicine accounts for more than 80% of the global market export share (75% of the raw materials for the production of Japanese Chinese medicine preparations are imported from my country).
Our company has established a complete database of Chinese herbal medicines: in recent years, we have analyzed the components of more than 3,000 kinds of Chinese herbal medicines through experimental analysis, and established a complete database of plant chemical components (fingerprints), which has laid a good foundation for the modernization of Chinese medicine research and development.
Preparation of original holographic Chinese medicine Holographic Chinese medicine: standardized Chinese medicinal materials or prescriptions, clarifying the interaction with the body, understanding and regulating the occurrence and development of diseases, and clarifying the pharmacodynamic evaluation system of traditional Chinese medicine theory. The visualized and materialized Chinese medicine efficacy evaluation system developed by our company is the first in the world. This evaluation system can complete the efficacy and toxicological evaluation of Chinese medicine within three months, solving the problem that Chinese medicine cannot be recognized by Western countries.
Using genomic technology to study the mechanism of Chinese medicine: Use genomic technology including RNAseq, MiRNAseq, etc. to study the mechanism of action of Chinese medicine and explain the efficacy at the molecular level. Applying modern genomic technology to the evaluation of efficacy can trace the source of Chinese medicine. Evaluating the efficacy at the genetic level is not only accurate and objective, but also can quantify the efficacy at the molecular level. Use modern infrared imaging technology to visualize the process of Chinese medicine action to study the efficacy. Use mass spectrometry technology to study the efficacy. Use mass spectrometry technology to materialize Chinese medicine (decompose and quantify the active ingredients) to study the efficacy.
Technical features: Biomanufacturing replaces traditional processes, with high efficiency. The time spent on the entire process is shortened by more than 80%. Low investment and low cost. The investment cost and pharmaceutical cost are about 10% of the traditional investment and pharmaceutical cost.
Comprehensive utilization: The drug residue can be made into biological herbicides, biological fertilizers, plant energy distillates, etc., and the materials are almost 100% utilized.
High purity: The purity reaches 99.9999999%, eliminating agricultural residues and heavy metals, high medicinal properties, non-toxic, high output, and high efficiency. It can carry out isomerization modification of Chinese herbal medicines, and the yield of the target component is as high as 99.99% (8% for decoction, about 40% for Japanese Kampo). The investment profit rate is extremely high.
Professional processing of cycloastragenol: All human-usable components in Chinese medicinal materials, including proteins, soluble carbohydrates, fats, secondary metabolites and minerals, are holographic Chinese medicines. Our company uses traditional Chinese medicinal materials as a reference and modern analytical instruments to prepare the chemical composition spectrum of the reference Chinese medicinal materials (called chemical holographic spectrum). On this basis, through ESM bioreactors and multi-stage countercurrent extraction technology, harmful substances (heavy metals, pesticide residues and toxic components, etc.) and Chinese medicinal components that cannot be used by the human body, such as cellulose and some hemicellulose, are removed to prepare extracts that retain as much as possible all human-usable components and are consistent with the chemical holographic spectrum of the reference medicinal materials. This extract is called "holographic Chinese medicine". Fully implement the feasible path of modernization of traditional Chinese medicine.